Medical history and physical examination:

• Primary care provider reviews medical history with physical examination
• Medication review
• Depression assessment (PHQ9)
• Neuropsychological testing
• Electrocardiogram (EKG)
• Sleep apnea testing (oximetry and/or sleep study)
• Memory testing
  • Mini-Mental State Examination (MMSE)
  • Montreal Cognitive Assessment (MoCA)

Radiology tests:

• MRI + volumetric analysis
• Metabolic FDG PET scan (questionable value)
• Amyloid PET scan
• Tau PET scan

Lab tests:

• Standard lab tests
  • Electrolytes, kidney, and liver function (CMP)
  • Complete blood cell count (CBC), Thyroid (TSH)
  • Vitamin B12, folate (B9), lipid panel
  • Urinalysis
• Advanced lab testing (considered)
  • Hemoglobin A1c (HbA1c)
  • Vitamin D
  • Erythrocyte sedimentation rate (ESR) and/or auto-immune panel
  • Omega-3 index
  • PrecivityAD™ (presence of amyloid plaque)
• Labs (rarely)
  • Urine toxicology screen, heavy metal screen, or free cortisol
  • Additional vitamin levels (B1, B3, B6)
• CSF testing (by lumbar puncture)
  • Amyloid Beta and Tau protein (AD markers)
  • Opening pressure, cell count, protein, and glucose